PRIMARY FUNCTION
Natural phospholipid supporting cognitive function, memory, learning, and healthy brain cell signaling in dogs and cats.
HOW IT SUPPORTS PET HEALTH
Phosphatidylserine (PS) is a major component of cell membranes, especially in the brain, where it plays a critical role in maintaining membrane fluidity, supporting neurotransmitter release, and facilitating neuronal communication. In companion animals, PS supplementation has been shown to support memory, learning, social behavior, and overall cognitive performance, particularly in aging dogs and those with cognitive dysfunction syndrome (CDS). PS may also help modulate stress responses and support adrenal health by influencing the release of certain hormones.
FUNCTIONAL OVERVIEW
– **Cognitive Support:** PS is concentrated in the brain and supports synaptic function, neurotransmitter release (including acetylcholine and dopamine), and receptor density, all of which are essential for memory and learning.
– **Neuroprotection:** PS may help protect brain cells from age-related decline and oxidative stress, and may slow the progression of cognitive dysfunction in senior pets.
– **Behavioral Benefits:** Clinical studies in dogs show that PS supplementation can improve social interactions, reduce disorientation, and decrease house-soiling and other signs of cognitive decline.
– **Stress Modulation:** PS may help regulate the stress hormone axis, supporting resilience to chronic stress.
– **Safe Plant-Based Sources:** Modern supplements use soy- or sunflower-derived PS, which have been shown to be effective and safe for pets.
COMMON VETERINARY USES
Species Studied
- Dogs
- Cats
Primary Benefits for Pets
- Supports Memory and Learning: Improves short-term memory and cognitive function, especially in aging dogs.
- Helps Manage Cognitive Dysfunction: Reduces symptoms of canine cognitive dysfunction syndrome (CDS), such as disorientation and changes in social behavior.
- Promotes Healthy Brain Aging: May protect against age-related neuronal loss and support long-term brain health.
- May Aid Stress Management: Modulates stress hormone production and supports adrenal health.
Veterinary Use Cases
- Adjunctive support for senior pets with memory loss or cognitive decline.
- Part of comprehensive protocols for brain health and behavior in dogs and cats.
- Potential support for stress resilience in pets with chronic anxiety or adrenal imbalance.
CONTRAINDICATIONS & SENSITIVITIES
Phosphatidylserine is generally well tolerated in dogs and cats at recommended doses, with rare mild digestive upset reported. Bovine-derived PS is no longer used due to safety concerns; modern supplements use plant-based sources. Always consult your veterinarian before starting a new supplement, especially for pets with chronic health conditions.
INGREDIENT SOURCING & QUALITY STANDARDS
High-quality PS supplements for pets are produced from non-GMO soy or sunflower lecithin and tested for purity and potency. Dosing is typically based on weight and tailored to the pet’s needs.
RESEARCH AT A GLANCE
- Neuroprotective and Cognitive Benefits: Phosphatidylserine supplementation improves memory, learning, and social behavior in aging dogs and supports healthy neurotransmitter function. URL: https://todaysveterinarypractice.com/neurology/management-of-dogs-and-cats-with-cognitive-dysfunction/
- Plant-Based PS and Safety: Soy-derived phosphatidylserine is as effective as bovine-derived PS for cognitive support, without the safety risks of animal-derived sources. URL: https://pubmed.ncbi.nlm.nih.gov/10501292/
- Memory Improvement in Dogs: Supplementation with phosphatidylserine and antioxidants improved short-term memory performance in aged beagles. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC2275342/
TRADITIONAL APPLICATIONS
Phosphatidylserine-rich foods (such as organ meats) have long been valued for supporting brain health and cognitive function in both humans and animals.
DISCLAIMER
This ingredient overview is intended for educational purposes only and should not be considered veterinary advice. Always consult with your veterinarian before introducing new supplements or making changes to your pet’s healthcare regimen.
